2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (514):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-180178
    BLIMP-1 ligand-1
    BLIMP-1 ligand-1 (Compound 56) is a BLIMP-1 ligand. BLIMP-1 ligand-1 can be used as a ligand for target protein for PROTAC to develop and design degraders of PROTAC BLIMP-1, such as PROTAC BLIMP-1 degrader-1 (HY-180177). BLIMP-1 ligand-1 can be used in multiple myeloma research.
    BLIMP-1 ligand-1
  • HY-181910
    SMARCA2 ligand-19
    SMARCA2 ligand-19 (Compound 26a) is a ligand for the target protein for PROTAC (SMARCA2). SMARCA2 ligand-19 can be used to synthesize PROTACs, such as SMARCA2 degrader-36 (HY-181909).
    SMARCA2 ligand-19
  • HY-179303
    DNPH1 ligand-1
    DNPH1 ligand-1 (Compound 58) is a DNPH1 ligand. DNPH1 ligand-1 can be used as a target protein ligand (Ligands for Target Protein for PROTAC) for the development and design of PROTAC DNPH1 degraders. DNPH1 ligand-1 can be used to synthesize PROTAC DNPH1 Degrader 1 (HY-179582).
    DNPH1 ligand-1
  • HY-185545
    NTRK1-ligand-1 2922277-92-5
    NTRK1-ligand-1 (Compound 15) is a NTRK1 ligand. NTRK1-ligand-1 serves as a Ligand for Target Protein for PROTAC, which is applicable to the development and design of PROTAC NTRK1 degraders, such as PROTAC NTRK1 degrader-1 (HY-181052). NTRK1-ligand-1 can be used in the research of solid tumors.
    NTRK1-ligand-1
  • HY-181036
    CDK12/13 ligand 3
    CDK12/13 ligand 3 is a CDK12/13 PROTAC ligand. CDK12/13 ligand 3 can be conjugated with E3 ligase ligand (HY-W093272) and linker to synthesize CDK12/13 PROTAC degrader DN1679 (HY-181035). CDK12/13 ligand 3 can be used for cancer research.
    CDK12/13 ligand 3
  • HY-177492
    NASA-linker-VH032-PEG3 ligand 99.58%
    NASA-linker-VH032-PEG3 ligand is a ligand that can be used to synthesize PROTACs.
    NASA-linker-VH032-PEG3 ligand
  • HY-170817
    SMI-1074 3033592-13-8
    SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers.
    SMI-1074
  • HY-W150930
    mTOR ligand 1 7597-22-0
    mTOR ligand 1 (compound T2) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). mTOR ligand 1 can serve as an active control for MHY1485 (HY-B0795, the target protein ligand of PD-M6 (HY-176166).
    mTOR ligand 1
  • HY-170354
    SMARCA2/4-ligand-4 3033592-40-1
    SMARCA2/4-ligand-4 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-4 can be used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347).
    SMARCA2/4-ligand-4
  • HY-182086
    Copanlisib-NH 2355277-02-8
    Copanlisib-NH is a PI3Kα/δ ligand. Copanlisib-NH can be used as a ligand for target protein for PROTAC to develop and design degraders of PROTAC PI3Kα/δ, such as PROTAC PI3Kα/δ degrader-1 (HY-182083). Copanlisib-NH can be used in breast cancer research.
    Copanlisib-NH
  • HY-150878
    AR ligand-4 2632308-13-3
    AR ligand-4 is an androgen receptor (AR) ligand, which can be used for the synthesis of PROTACs, such as ARD-1676 (HY-156111).
    AR ligand-4
  • HY-178826
    LSD1-IN-45
    LSD1-IN-45 is an LSD1 inhibitor and a ligand for the target protein for PROTAC. LSD1-IN-45 can be used to synthesize PROTAC LD-110 (HY-178825).
    LSD1-IN-45
  • HY-170373
    RET ligand-1 3028787-16-5
    RET ligand-1 is a target protein ligand targeting RET that can be used to synthesize PROTAC LDD39 (HY-159967).
    RET ligand-1
  • HY-170303
    AR ligand-32 2505498-74-6
    AR ligand-32 is a target protein ligand, used for the synthesis of PROTAC AR Degrader-7 (HY-160221).
    AR ligand-32
  • HY-175456
    AR-DBD ligand-1 3108871-05-9
    AR-DBD ligand-1 is an AR-DBD ligand. AR-DBD ligand-1 can be used to synthesize PROTAC LYA914 (HY-175455).
    AR-DBD ligand-1
  • HY-182810
    CDK9 ligand 5 3079792-42-7
    CDK9 ligand 5 (Compound 48) is a CDK9 ligand. CDK9 ligand 5 can be used as a ligand for target protein for PROTAC to develop and design degraders of PROTAC CDK9, such as PROTAC CDK9 degrader-9 (HY-168518). CDK9 ligand 5 can be used in cancer research.
    CDK9 ligand 5
  • HY-175526
    Aurora kinase ligand-1 1907679-70-2
    Aurora kinase ligand-1 (Compound I-4) is an Aurora kinase B (AURKB) PROTAC ligand. Aurora kinase ligand-1 can be conjugated with E3 ligase Ligand (HY-112078) and linker to synthesize AURKB PROTAC degrader MS44 (HY-175525). MS44 can be used for cancer research.
    Aurora kinase ligand-1
  • HY-179597
    ERα ligand 3
    ERα ligand 3 is a PROTAC target protein ligand that targets ERα. ERα ligand 3 can be used for the synthesis of CV2a (HY-179576).
    ERα ligand 3
  • HY-168449
    BAZ2A/B ligand 1
    BAZ2A/B ligand 1 (compound 1) is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). BAZ2A/B ligand 1 can be used for synthesis dBAZ2 (HY-168448).
    BAZ2A/B ligand 1
  • HY-W754809
    ALK ligand-1 2353496-79-2
    ALK ligand-1 is a ALK ligand that can be used for synthesis of PROTAC ALK degrader-4 (HY-175527).
    ALK ligand-1